Research interests at TOMSBio lab
Plants manufacture specialized metabolites that aid in the interaction and survival with their environment. These compounds, referred to as ‘secondary metabolites’, constitute a rich source of health benefits in human nutrition but also represent the building blocks in the development of novel pharmaceuticals. However, secondary metabolism is limited to occurrence, and some compounds are temporally and spatially restricted to certain taxonomic groups.
Development and secondary metabolism are tightly connected processes. Part of this association depends on differential gene expression: while the information is instructed and hardwired in the genome, its regulation and display in certain cell types will ultimately determine the capacity to accumulate different metabolites. The control of secondary metabolism in response to developmental and environmental cues is exerted by transcription factors and transcriptional co-regulators acting on cis-regulatory DNA sequences that determine when, where, and how genes are expressed, but also on other types of regulatory proteins and RNAs.
At TOMSBio lab we are interested in the transcriptional regulation of secondary metabolism. This has included genomic analyses of transcription factor families and global gene expression analyses, as well as an interest in systems biology approaches integrating transcriptomics and metabolomics datasets. The current focus of the laboratory is the study at a global level of gene regulatory networks that control phenylpropanoid and isoprenoid metabolism in climacteric and non-climacteric fleshy fruits, such as tomato (Solanum lycopersicum) and grapevine (Vitis vinifera), respectively. We are also interested in several other species holding potential pharmaceutical properties that make them important for drug discovery and improvement of functional foods.
Our laboratory is in the Program for Systems Biology of Molecular Interactions and Regulation at the Institute of Integrative Systems Biology (I2SysBio, Research group of Dr. José Tomás Matus Picero). We promote respect and tolerance and are openly pro of diversity of all kinds.
Lines of Research
Integrative omics approaches to identify novel regulators and novel enzymes of specialized metabolism
We associate transcriptomic and metabolomic data in plant organs or cell cultures to isolate unknown secondary metabolic enzymes and their transcriptional regulators.
Development of Apps and web tools to explore, integrate and visualize omics data in non-model species
We build Plant Visualization Platforms to visualize omics data, explore through gene catalogue repositories, expression heatmaps and 2D gene co-expression networks. We also integrate transcriptomics and metabolomics data, and much more!
Use of multi-omics tools to unravel plant communication mechanisms mediated by specialized metabolites.
We are interested in decoding plant-to-plant and plant-to-insect communication, to understand how plants interact with their environment for improving their fitness. We aim to unveil different communication channels and to identify the mechanisms for message reception and emission in plants. Multidisciplinar projects are currently nurturing this line of research.